This one-day regional meeting of statisticians, engineers, computer scientists, mathematicians, and practitioners interested in the theory and applications of Statistical Machine Learning is being organized by the ISU Departments of Industrial & Manufacturing Systems Engineering and of Statistics. The purpose of the meeting is to bring together a diverse set of researchers and practitioners from multiple disciplines to discuss current motivating problems and methodological advances in theory-based machine learning. There was excellent attendance and a stimulating program at the inaugural Colloquium in 2018 and our intention is to follow the same format. The Colloquium will be a single-track event with six invited plenary presentations by top experts from Midwestern universities and research organizations, with an additional substantial poster session.